This study investigated relationships among the use of web and human resource during science class and science career interest. Results suggested that levels of science career interest could be predicted based on classroom use of web and human resources. Regular use of human resources was predictive of science career interests for boys and girls. Use of web resources was only predictive of girl's interests, on average, 7 points higher on a 36-point scale than girls who did not use web resources. Girls who used both resources scored 16 points higher than girls who used neither. Two other predictor variables found included (1) teachers who lacked science background and used web resources regularly and (2) level of student-centered instructional strategies used in the classroom. Further research is suggested.