The Bureau of Indian Affairs (BIA) created the Relocation Program in 1952 to sever Indian federal trust status and impose Euro-American values on Indians all under the guise of benevolence. Led from reservations to urban areas, Indians found the problems of their reservations in their new locations: few employment opportunities, poor housing conditions, and failing school programs. In Chicago's Uptown neighborhood, Indians and those concerned with Indian welfare developed organizations in response to the pressing needs of the Indian community, especially the high dropout rate for Indian students (estimated as high as 90 percent). St. Augustine's Center for American Indians, the American Indian Center, and the Native American Committee established a variety of programs designed to promote Indian culture, history, values, and academic success. Beginning in 1970, the American Indian Center and the Native American Committee worked with the Chicago Board of Education to develop the Little Big Horn Program, an urban high school and preschool program designed specifically for the needs of Indian students. The Little Big Horn Program brought about a new beginning for Indian education in Chicago: one where the Indian voice could direct the course. This article provides an educational history of the American Indian experience in Chicago from 1952-1972.