Truant youths represent a critical group needing problem-oriented research and involvement in effective services. The limited number of studies on the psychosocial functioning of truant youths have focused on one or a few problem areas, rather than examining comorbid problem behaviors. The present study addresses the need to examine the interrelationships of multiple domains of psychosocial functioning, including substance involvement, mental health, and delinquency, among truant youths. Exploratory structural equation modeling on baseline data collected on 219 truant youths identified two major factors reflecting psychosocial functioning and found that the factor structure was similar across major sociodemographic subgroups. Further analyses supported the validity of the factor structure. The research and service delivery implications of the findings are discussed. (Contains 3 tables and 1 figure.)