Positive psychology has received increasing attention in rehabilitation counseling research and practice. The rehabilitation counseling philosophy shares a similar emphasis of personal assets and strengths, which provides a solid foundation for the integration of positive psychology into the professional practice of rehabilitation counseling. In this article, the guest editors present their rationale for developing this special issue on positive psychology and rehabilitation research. They highlight some of the exciting findings reported in the articles included in this special issue on positive psychology and rehabilitation research. The goal of this special issue is to stimulate thinking and discussion about applying positive psychology theory, research, assessment, and interventions in rehabilitation counseling for promoting overall well-being, quality of life, and happiness for people with chronic illness and disabilities.