Use of portable electronic devices by persons with moderate intellectual disabilities and autism spectrum disorders is gaining increased research attention. The purpose of this review was to synthesize twenty-first century literature (2000-2010) focusing on these technologies. Twenty-one studies were identified which evaluated use of: (a) handheld computers; (b) cellular phones; and (c) MP3 players across various skills and settings to assist persons with disabilities. Guidelines and recommendations for instruction and future research are provided. (Contains 1 table and 7 figures.)