This paper discusses the contributing factors that influence students' acquisition of manipulative skills. Incompetence in manipulative skills in science at a primary level may impede science learning at secondary school. Thus, to confront these issues, an in-depth study was conducted. The research involved 10 primary school students who were interviewed again in secondary school. This paper gives an account of the factors that influence students' manipulative skills during transition from primary to secondary school, namely the teacher, the performance of the students, teaching and learning aspects and the physical environment of the laboratory. The results suggest several issues to be considered when teaching manipulative skills. Primary school students need to be exposed to these skills in using scientific apparatus so that when they enter secondary school, attention can be given in improving and strengthening those skills.