Within the framework of problem behavior theory, the purpose of this study was to examine risk behavior profiles of typical and atypical adolescents and the differential outcomes of well-beings for these individuals in the United States. Based on the data from the survey of Health Behavior of School-Aged Children by World Health Organization, multidimensional scaling profile analysis was used to identify prototypical risk behavior profiles and atypical adolescents. Analyses suggested prototypicality of risk behavior patterns rather than a risk behavior syndrome. The regression analysis was then conducted to investigate the effects of atypical individuals vs. prototypical risk groups on well-being outcomes. The results indicated that those adolescents who were identified as more atypical than typical reported less positive psychological outcomes. (Contains 5 tables and 1 figure.)