Performance as measured by grades in the first and second semesters of organic chemistry was predicted using pre-college measures (SAT scores, high school rank, validation exams) and college measures (general chemistry GPA, overall college GPA prior to beginning organic chemistry, first-semester organic chemistry GPA). Data indicate that overall college GPA prior to organic chemistry is the best predictor of first-semester organic chemistry GPA. First-semester organic chemistry performance is the best predictor of second-semester organic performance. The ability of faculty to reasonably predict how students will do in organic chemistry is particularly applicable in academic program and career advising, especially for students pursuing medical school. (Contains 4 tables.)