Since students' misconceptions are not completely remedied by means of only one conceptual change method, the authors assume that using different conceptual methods embedded within the 5E model will not only be more effective in enhancing students' conceptual understanding, but also may eliminate all students' misconceptions. The aim of this study is to display a sample teaching of the cell and its organelles by combining different conceptual change methods (analogy, conceptual change text and worksheet) within the 5E model. But, the study has a shortcoming in seeking the degree to which conceptual change is achieved. For this reason, further research should focus on applicability of the presented teaching design in a comparative manner. (Contains 1 table and 2 figures.)