When President Barack Obama tapped Dr. Regina Benjamin, a rural Alabama family physician, to serve as U.S. Surgeon General, she joked that her client base went overnight from several hundred to nearly 300 million. Dr. Benjamin, an alumna of historically Black Xavier University of Louisiana and Morehouse School of Medicine, was busy tending to the needs of her diverse patient group for 23 years as head of the La Batre Rural Health Clinic. Now, she is just as busy in her new capacity helping the Obama administration devise and promote healthy living initiatives. As Surgeon General in the U.S. Department of Health and Human Services, Benjamin has the official rank of vice admiral, overseeing the operational command of 6,500 uniformed health officers around the world. Dr. Benjamin leads the effort to focus the nation on exercise and other strategies to promote health and wellness. This article presents an interview with Dr. Benjamin in which she shares her views on a range of issues.