This study presents the development of a new instrument, the "Multidimensional Attitudes Scale Toward Persons With Disabilities" (MAS). Based on the multidimensional approach, it posits that attitudes are composed of three dimensions: affect, cognition, and behavior. The scale was distributed to a sample of 132 people along with a self-esteem measure and a frequently employed attitude scale, the "Attitudes Toward Disabled Persons Scale" (ATDP). The construct and concurrent validity of the questionnaire was demonstrated by reliability and factor analyses, as well as by comparison with the ATDP scale. Principal component factor analysis revealed three correlated but distinct factors. Results show that women hold more positive behavioral attitudes than men. Interestingly, men with high self-esteem were found to hold more positive cognitions than men with low self-esteem. Results indicate the importance of a multidimensional approach both for the construction of sound instruments and for professional interventions aimed at modifying attitudes toward persons with disabilities.