The Personality Psychopathology Five (PSY-5) is a model of personality psychopathology assessed in adult populations with a set of Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales. The authors examine the reliability and validity of recently developed lower-order facet subscales for each of these five domains, with an emphasis on structural invariance, using both confirmatory factor analysis (CFA) and exploratory factor analysis (EFA). MMPI-2 protocols completed by psychiatric patients (N = 693) served as the data source. The reliability and discriminant validity of the subscales were mostly inadequate. Results from the CFAs reveal universally poor statistical fits. Subsequent EFAs extracted alternate latent structures, which also demonstrate mostly inadequate reliability and validity. Overall, results suggest that the item pool that forms the MMPI-2 PSY-5 domain scales may not be able to sustain meaningful facet subscales. (Contains 4 tables and 6 notes.)