The authors review research on the risk factors for, and prevalence of, psychological disorders as they relate to gender nonconformity in adolescence and adulthood. Findings from existing literature suggest gender nonconforming individuals are more likely to experience a variety of risk factors associated with psychopathology when compared with general and sexual minority populations. Associated with these risk factors, gender nonconforming individuals also report higher rates of psychopathology as well. The authors propose more research that examines gender nonconformity as an independent line of inquiry that transcends sexual orientation and gender identity.