ERIC Number: EJ1042877
Record Type: Journal
Publication Date: 2014-Nov
Pages: 13
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
EISSN: N/A
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder
Cooper, Miriam; Thapar, Anita; Jones, Derek K.
Journal of Autism and Developmental Disorders, v44 n11 p2742-2754 Nov 2014
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
Descriptors: Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Attention Deficit Hyperactivity Disorder, Males, Adolescents, Comparative Analysis, Correlation, Severity (of Disability), Brain Hemisphere Functions, Comorbidity
Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A