The first in a series of three publications which address the prevention and treatment of developmental handicaps, this volume includes sections on developmental issues and the consideration of linkages. Section I includes the four following papers: "Early Intervention: The State of the Art" (N. Johnson and H. Chamberlin); "Intellectually Limited Mothers" (R. Kaminer and H. Cohen); "Relationship of Prenatal Care to the Prevention of Mental Retardation and Other Problems of Pregnancy Outcome" (C. Berg and I. Emanuel); and "The Human Cost of Chronic Illness" (H. Ireys and P. Magrab). The second section focuses on existing working arrangements, or linkages, between Title V Maternal and Child Health programs and university affiliated facilities (UAFs) which train personnel in interdisciplinary service delivery, conduct research, and provide services to persons with developmental disabilities and other multiply handicapping conditions. Included in this section are examples of current working relationships and a review of changes occurring within Title V programs that will affect future agreements. (JW)