This paper explored and described the analogical reasoning occurring in the minds of different science achievement groups for the concept of translation in protein synthesis. "What is the process of self-generated analogical reasoning?", "What types of matching was involved?" and "What are the consequences of the matching processes?" were some of the research questions asked. The data was collected in multiple forms using the Translation Analogy Task (TAT), structured interviews, students' journals, researcher's observations (classroom and during interviews) and audit trail. 99 participants from a Matriculation College in the vicinity of Kuala Lumpur, Malaysia participated in this study. The participants were categorised as low, average and high achievers using the Translation Test (TT) results. The findings were put forth in the form of a model of Self-Generated Analogical Reasoning (SGAR). (Contains 1 table, 2 figures, and 1 note.)