Bullying, aggression, and peer victimization among adolescents are significant public health concerns. Recent research has demonstrated that bullying and peer victimization sometimes include homophobic epithets directed at heterosexual and lesbian, gay, bisexual, and transgender (LGBT) youth. It appears that being at the receiving end of homophobic banter generally contributes to worse outcomes among youth. This article highlights methodological issues in conducting research with LGBT youth, and stresses the importance of using theoretically and empirically supported definitions, including youth who are sexually questioning, focusing on multiple social and cultural contexts, and examining how support networks serve as buffering agents with regard to the effect of homophobic bullying on psychological outcomes.