International entrepreneurship and knowledge-based entrepreneurship have recently generated considerable academic and non-academic attention. This paper explores the "new" field of knowledge-based entrepreneurship in a boundless research system. Cultural barriers to the development of business opportunities by researchers persist in some academic contexts, where the focus is on "pure" research rather than the exploitation of results. The promotion of "invisible networks" of peers and the provision by higher education institutions of the kind of entrepreneurship education needed by scientists if they are to transform their research results into successful businesses are among the appropriate strategies to connect research with entrepreneurship in an international context. (Contains 14 notes and 1 figure.)