This Monte Carlo simulation study investigated methods of forming product indicators for the unconstrained approach for latent variable interaction estimation when the exogenous factors are measured by large and unequal numbers of indicators. Product indicators were created based on multiplying parcels of the larger scale by indicators of the smaller scale, multiplying the three most reliable indicators of each scale matched by reliability, and matching items by reliability to create as many product indicators as the number of indicators of the smallest scale. The unconstrained approach was compared with the latent moderated structural equations (LMS) approach. All methods considered provided unbiased parameter estimates. Unbiased standard errors were obtained in all conditions with the LMS approach and when the sample size was large with the unconstrained approach. Power levels to test the latent interaction and Type I error rates were similar for all methods but slightly better for the LMS approach. (Contains 4 tables.)