Partnerships and collaborative projects among public schools and universities have become increasingly prominent in the educational landscape. Properly structured and carefully managed school-university initiatives can enrich educational opportunities and contribute to simultaneous and continual quality improvement of the partnering entities. In this article, we provide 10 design principles intended to serve as a blueprint for organizational leaders engaged in formation of such school-university ventures. These principles attempt to minimize organizational conflict by ensuring that partnership leaders delineate joint work purposes and expectations, form collaborative work processes, clarify respective financial and logistical obligations, and specify decision responsibilities and job duties. These principles call for development of internal structures and processes that identify potential conflict points and establish measures for resolution when conflicts arise. We describe characteristics of school-university partnerships with discussion of the challenges and implications of implementing the principles to control interorganizational conflict.