Students who engage in high-risk behaviors, including early initiation of sexual intercourse, alcohol use, marijuana use, tobacco use, and externalizing behavior are vulnerable to a broad range of adverse outcomes as adults. Latent class analysis was used to determine whether varying patterns of risk behavior existed for 212 urban African-American students from Baltimore public schools who were recruited as part of a study for the prevention of drug use. A two-class model was estimated. The proportion of the sample bearing a high probability of each of the five risk behaviors was 10.7%; in comparison, the proportion of students with a low probability of the risk behaviors was 89.3%. Controlling for other variables, older age and parental drug or alcohol use was associated with being in the high-risk class, whereas neighborhood was not predictive of latent class. Results from this study may be used to target early adolescents with co-occurring risk behaviors for prevention and treatment. (Contains 1 table and 1 figure.)