Children who have experienced relational trauma present a host of problems and are often diagnosed with psychiatric disorders and then medicated. But there is evidence that commonly used drugs interfere with oxytocin or vasopressin, the human trust and bonding hormones. Thus, psychotropic drugs may impair interpersonal relationships and impede forming a therapeutic alliance. One prominent characteristic of trauma is that the safety within interpersonal connectedness is disrupted. These breaches of trust, respect, safety, and collaboration with adults further impair children's ability to recover from traumatic experiences. They become dysregulated, impulsive, moody, aggressive, untrusting, and withdrawn. These troubled youth become wary of adults. They receive wide-ranging diagnoses. A youth who becomes too impaired (or symptomatic) is often swept up into the realms of psychiatric and psychological treatment. Moreover, it is often believed that the combination of these disciplines can result in optimal outcomes for these children. This article provides a brief overview of the different classes of medications that troubled youth are typically prescribed. The use of medications in youth is not well researched and becomes particularly complex when considering developmental aspects of children, their histories, the use of multiple, concurrent medicines (polypharmacy), and the supportive networks in their lives. Nonetheless, research does provide some insight as to how these medications may affect the ability of a child to connect when in treatment.