Objective: The objective of this study was to assess male undergraduate students' human papillomavirus (HPV) knowledge and intentions to receive the HPV vaccination. Design: Cross-sectional survey. Method: A sample of 116 male undergraduate students from a university in the Midwestern USA completed a survey questionnaire assessing various aspects related to their attitudes towards the HPV vaccine. Results: Results show that awareness and levels of knowledge about HPV and the HPV vaccine were low among male undergraduate students. The study also found that intentions to receive the HPV vaccine were very low among this population. Conclusion: The results of this study should encourage the developmental and implementation of campus-wide health education programmes which discuss the HPV vaccine and benefits for men.