This study examines how United States (US) teachers' experiences and beliefs may be predictive of their intervention in anti-lesbian, gay, bisexual, and transgender (LGBT) bullying and harassment using a US national sample of teachers (N?=?726) who completed an online survey. Results from regression analysis indicated that knowing LGBT people, awareness of general bullying and harassment, awareness of anti-LGBT bullying and harassment, and self-efficacy related to intervention in homophobic remarks were significant predictors of teachers' frequency of intervention in homophobic remarks. Teachers' sense of obligation to ensure safe schools for LGBT youth was not predictive of intervention. Implications for teacher education include: providing opportunities for exposure to LGBT people; raising awareness of anti-LGBT bullying and harassment; and building teachers' skills to intervene in anti-LGBT behaviors.