One key step in the evidence-based practice process directs practitioners to pose client-oriented, practical, evidence-search questions (COPES), seeking the truth about what will help their client (Gibbs, 2003) and inform policy (Gambrill, 2006) and not to take a "one method fits all" position. Literature focusing on providing services to minority children and families in the child welfare system strongly supports this approach (Cohen, 2000; Lum, 2004; Samantrai, 2004). This article poses an effectiveness question, locates and evaluates existing evidence, and then presents implications for working with families and children from diverse backgrounds. The effectiveness question posed is, "If families and children from diverse populations experiencing mental health problems receive Multisystemic Therapy, will they have similar outcomes across race and ethnicity?" (Contains 1 table.)