A path model was utilized to determine the relationship of demographic, family system, adolescent perceptions of parental behavior, and youth characteristics to adolescent substance abuse. Self-report questionnaire data were collected from 214 high school students at two high schools in a southwestern state. Results showed direct positive relationships of adolescent reports of parental substance use and adolescent reports of parental support with adolescent reports of substance use. Indirect relationships were found for school, gender of the adolescent, family hardiness, family coherence and parental substance use to perceived parental support to adolescent substance use. Implications are presented for prevention and intervention at multiple levels of the family system in relation to adolescent substance use.