The "Profile of Mood States 2nd Edition" (POMS 2) was published in 2012 by Multi-Health Systems (MHS) to assess transient feelings and mood among individuals aged 13 years and above. Evolving from the original POMS (McNair, Lorr, & Droppleman, 1971, 1992), the POMS 2 was designed for youth (13-17 years old) and adults (18 years old and above) to measure their affective traits, moods, and emotions. The POMS 2 contains four self-report versions: the "Profile of Mood States 2nd Edition-Adult" (POMS 2-A), the "Profile of Mood States 2nd Edition-Youth" (POMS 2-Y), the "Profile of Mood States 2nd Edition-Adult Short" (POMS 2-A Short), and the "Profile of Mood States 2nd Edition-Youth Short" (POMS 2-Y Short). The POMS 2 is applicable and useful to multiple settings. For clinical practitioners, the POMS 2 instruments can monitor change in mood disturbance during or following intervention. In medical settings, the POMS 2 helps to assess the impact of diagnosis and treatment of physical disease on psychological functioning. In the athletic domain, the test can be used to study the relationship between mood and exercise or physical activity. Reliability and validity evidence has been provided in this article from several analyses.