Three million Americans have epilepsy, a chronic neurological condition characterized by recurrent epileptic seizures unprovoked by any known cause. Those at risk for epilepsy include individuals with mental retardation, cerebral palsy, autism, stroke, major head trauma, central nervous system (CNS) hemorrhage, CNS infection, dementia, and brain tumor. Of this group, 300,000 have a first convulsion each year, and 120,000 are under 18 years of age. With 326,000 school children through age 14 diagnosed with epilepsy, seizure preparedness and expanded awareness and education on what to do when a child has a seizure while at school is an extremely important and complex issue being faced by parents of children with this disability. This article discusses the necessity of a seizure emergency plan. It also provides strategies for the administration of emergency antiepileptic medication within the school environment.