This study examined the impact of positive psychological traits (positive coping, self-efficacy, and self-esteem) on the relationship between seizure severity and life satisfaction among individuals with epilepsy. Hierarchical regression analysis and correlation techniques were used to test a hypothesized tri-mediation model of life satisfaction for individuals with epilepsy. Results indicated that seizure severity and positive human traits, including positive coping, self-efficacy, and self-esteem, were indeed associated with overall life satisfaction. Self-efficacy and self-esteem (but not positive coping) fully mediated the relationship between seizure severity and life satisfaction, lending support for a dual-mediation model. These findings suggest there may be considerable value for rehabilitation psychologists and counselors to develop specialized intervention programs that focus on capitalizing these positive human traits to promote life satisfaction and well-being for clients with epilepsy.