This article focuses on the understudied role of research groups contributing to develop the knowledge base of developing universities in regions lagging behind in human, financial and scientific resources. We analyse the evolution of a research group that, in less than 10 years, achieved worldwide recognition in the field of microelectronics, with an impact on both engineering research and teaching activities at the University of Macau. Our analysis concludes that voluntarism and loose organizational structures from the start stimulate the development of solid scientific agendas and institutional identity, and that counter-intuitive policies, including academic inbreeding, may also be needed and unavoidable in this effort. The use of these counter-intuitive policies and their effects, however, can be mitigated by transforming education to highlight high levels of internationalization and quality standards with measurable outcomes. This requires the committed involvement of research group leaders in both research and education. Lastly, another key component of university development may lie in hiring and giving freedom to young promising scholars with the will and drive to lead and act.