Which comprehensive school reform programs have evidence of positive effects on middle and high school achievement? To find out, this review summarizes evidence on comprehensive school reform (CSR) models in grades 6-12. Comprehensive school reform models are programs used schoolwide to improve student achievement. They typically include the following elements: (1) Innovative approaches to instruction and curriculum used in many subjects throughout the school; (2) Extensive, ongoing professional development, and coaches or facilitators in the building to help manage the reform process; (3) Measureable goals and benchmarks for student achievement; and (4) Emphasis on parent and community involvement. CSR models are developed and supported by national organizations, mostly nonprofits, that provide professional development, materials, and support to networks of schools. Overall, 197 studies on 18 national programs were reviewed. Of these, 15 studies were rated "conclusive," and 12 were rated "suggestive."