The construct of emotion dysregulation increasingly has been used to explain diverse psychopathologies across the lifespan. The Difficulties in Emotion Regulation Scale (DERS; K. L. Gratz & L. Roemer, 2004) represents the most comprehensive measure of the construct to date and exhibits good reliability and validity in adults; however, the measure has yet to be tested in adolescents. The present study examined the psychometric properties of the DERS in a community sample of 428 adolescents (ages 13-17 years). Exploratory factor analysis supported a 6-factor structure consistent with the 6 DERS subscales. Internal consistencies for the subscales were good to excellent (alphas ranged from 0.76 to 0.89). In support of the measure's construct validity, the DERS exhibited robust correlations with psychological problems reflecting emotion dysregulation, specifically depression, anxiety, suicidal ideation, eating disorders, alcohol use, and drug use. Intercorrelations among the DERS subscales ranged from negligible to high (range: r = 0.04 to r = 0.68), and potential problems with discriminant validity were noted. In general, results support the reliability and validity of the DERS as a measure of emotion dysregulation in adolescents. (Contains 3 tables.)