ERIC Number: EJ979747
Record Type: Journal
Publication Date: 2012-Jan
Pages: 7
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
Integrated Teaching of Structure-Based Drug Design and Biopharmaceutics: A Computer-Based Approach
Sutch, Brian T.; Romero, Rebecca M.; Neamati, Nouri; Haworth, Ian S.
Journal of Chemical Education, v89 n1 p45-51 Jan 2012
Rational drug design requires expertise in structural biology, medicinal chemistry, physiology, and related fields. In teaching structure-based drug design, it is important to develop an understanding of the need for early recognition of molecules with "drug-like" properties as a key component. That is, it is not merely sufficient to teach students how to design an effective inhibitor for a particular protein; instead, it is important to convey the need for simultaneous consideration of biopharmaceutical properties that will optimize the chances of the inhibitor becoming a drug. These are advanced concepts, but they can be addressed through computer-based methods. Here, an educational approach using a case study is described in which students "design" a potential drug through use of software, most of which is Web-based and freely available. (Contains 2 tables and 3 figures.)
Descriptors: Biology, Chemistry, Physiology, Science Instruction, Computer Uses in Education, Scientific Concepts, Computer Software, Case Studies, Educational Technology, Internet, Teaching Methods, Student Projects
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A