Medications are the primary treatment for epilepsy, yet many teens and their families have problems managing seizure medicines. Fear of side effects, difficulties remembering to take medicines and figuring out how to take them are common challenges. Unfortunately, not taking medicine as prescribed can lead to breakthrough seizures, which in turn can cause falls, injuries or seizure emergencies. Loss of seizure control can also lead to the loss of a driver's license. This article explores the practical aspects of managing medications for seizures--why they are needed, how they are selected and prescribed and how people can manage them most effectively.