Nurse educators, at every level of pre-licensure nursing education, are charged with developing critical thinking skills within their students. Post-clinical conference is one teaching strategy that nurse educators can employ to help promote the development of critical thinking skills in pre-licensure nursing students. However, traditional face-to-face post-clinical conference is marred with issues and concerns, as identified in the nursing education literature. An alternative to face-to-face post-clinical conference, asynchronous online learning environment, mitigates the issues and concerns associated with traditional post-clinical conference. Adult learning theory supports the use of asynchronous online learning environment. The asynchronous online learning environment promotes student-centered teaching strategy in place of teacher-centered learning, which by its nature traditional face-to-face post-clinical conference tends to support. The purpose of this comparison group pretest/posttest quasi-experimental study was to determine the effect of online clinical post-conference on critical thinking in comparison to face-to-face post-conference in associate degree nursing students enrolled in a pre-licensure program. The study used a small convenience sample of students enrolled in an associate degree nursing program at a mid-Atlantic community college. The study participants were given the California Critical Thinking Test at the start of their primary medical-surgical nursing clinical course and again at the end of that course. Twenty-one students were placed into the control group, traditional face-to-face post-clinical conference, and 23 students were placed into the treatment group, asynchronous online post-conference. The results showed that the intervention, online post-conference, did not impact the participants' ability to critically think. The data analysis did not support the research question that the implementation of online post-conference would improve students' ability to critically think. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]