This study investigated predictors of depression in 278 African-American, 206 European-American, and 122 Hispanic teen mothers approximately 36 months after the birth while controlling for depression 14 months after the birth. Predictor variables were age, ethnicity, mastery, knowledge of development, and parental distress. Younger teens were not more depressed than older teens. Although there were not significant differences by ethnicity in 14 month depression, significant differences were evident at 36 months. European-American mothers were the most depressed, whereas Hispanic mothers were the least depressed. Parental distress was positively associated with depression at 36 months while controlling for depression at 14 months. This study provides information for targeting teen mothers at the highest risk for depression through the toddler years, as well as spurs ideas for intervention strategies. (Contains 3 tables.)