This study investigates whether pre-service teachers' learning approach and gender are related to their technological knowledge, their technological content knowledge, their technological pedagogical knowledge and their technological pedagogical content knowledge. The sample of the study consisted of 239 pre-service teachers. It was found that an instructional technology and material development course had a positive effect on pre-service teachers' technological knowledge, technological pedagogical knowledge and technological pedagogical content knowledge. Furthermore, technological knowledge, technological content knowledge, and technological pedagogical knowledge accounted for 82% of the variance in technological pedagogical content knowledge. Students having a deep learning approach and a deep surface learning approach had significantly higher technological knowledge, technological pedagogical knowledge and technological pedagogical content knowledge scores after the course than before the course, but there were no significant differences between surface learning approach students' scores before and after the course.