ClassWide Peer Tutoring (CWPT) is an evidence-based instructional strategy effective with students with and without disabilities. The evidence for efficacy is strong with respect to students in elementary schools learning basic academic skills in classrooms with large teacher-pupil ratios, and relatively less strong for students in secondary schools learning academic content skills in general education classrooms. Largely unknown, however, is the efficacy of CWPT with secondary level students with emotional and behavioral disorders (E/BD) in alternative schools with small teacher-pupil ratios. Known challenges to the efficacy of CWPT in these settings are the smaller class sizes with smaller peer groups, the high number of students in class with significant behavioral issues, and the absence of typically developing peers. Collectively, these challenges may obviate the operation of some components of CWPT contributing to its efficacy, such as novelty in weekly peer tutors or ability of peers to praise and provide response feedback. The purpose of the present investigation was to make an initial examination of CWPT used in these conditions. In two alternative school classrooms, students and teachers participated in an ABAB single-subject design comparing the current instruction (conventional) with CWPT. Results based on students' weekly biology test scores were not superior with CWPT in one classroom, and only slightly improved in the second. Based on these findings, Class-Wide Self-Management (CWSM) was added to CWPT and compared to conventional instruction in a third classroom (spelling) using an alternating treatment design. Similar test results for these students indicated sizable improvements in most, but not all, weeks of the study. Students in all three classrooms improved in the amount of time spent on-task in CWPT compared to conventional instruction. Implications for research and practice are discussed. The following are appended: (1) Front Page of CWPT Point Sheet; (2) Front Page of CWPT Point Sheet with Citizenship Points (CWSM); and (3) Sample Fidelity of Implementation/Procedural Checklist Items. (Contains 1 table and 3 figures.)