Schools with large numbers of students falling off the graduation path need comprehensive reforms that create a solid foundation of high-quality instruction and positive behavioral supports for all students. They also need data-driven response systems that provide targeted and intensive interventions for students who need additional academic and social supports. This article offers a systematic plan for dropout prevention at the district and school levels that integrates research-based recommendations into a coherent, three-tiered model. The model provides a way to coordinate all types of interventions and replace the patchwork of fragmented programs that often allows students to fall through the cracks. (Contains 17 notes.)