Between 1980 and 1993, only 19% of medical school graduates chose faculty appointments with research responsibilities. Women and minorities represent only a small fraction of these, despite their growing numbers. The authors' goal is to study the effects of human agency, particularly self-efficacy, on the career development of physician researchers, especially women and people of color; therefore, we developed a reliable and valid inventory for assessing clinical research self-efficacy in a population of physicians training for clinical research careers. Scale items were pooled from expert knowledge, relevant literature, and existing inventories to create a 92-item Clinical Research Appraisal Inventory that was factor analyzed and refined to include 88 items. Although instruments have been developed to successfully assess research self-efficacy, this is the first instrument designed to assess self-efficacy in the clinical research domain using a population of academic physicians. (Contains 6 tables and 1 note.)