Human papillomavirus (HPV), the most common sexually transmitted virus in the world, is associated with almost all cases of cervical cancer. It is also related to vulvar, vaginal, penile, anal, and oropharyngeal cancer. HPV vaccination is recommended by the Centers for Disease Control and Prevention (CDC) for both boys and girls. Unfortunately, because prevention efforts have focused primarily on young women, many young men are unaware of the virus, its consequences, or preventive strategies. The purpose of this study was to determine knowledge level of HPV, perceived risk of HPV and intent to obtain HPV vaccination among male university students. Participants completed a 31-item survey. Knowledge-based questions indicated rudimentary knowledge of HPV. Fifty percent knew that HPV was the most common STI, over half (52%) knew of the HPV association with multiple cancers, 39% could correctly identify the virus and 35% could identify virus strains controlled by vaccination. Most agreed (54%) or strongly agreed (19%) they were at a high risk for HPV. A significant majority agreed (49%) or strongly agreed (39%) that unprotected sexual activity put them at risk but nearly half (46%) were unaware that HPV vaccinations were available for males. Despite this awareness, 86% were not vaccinated and 65% of these respondents did not plan to become vaccinated. In addition, of 86% who were not vaccinated, 45% did not perceive themselves at risk and 47% were not aware of a vaccination. Only 9% were fully vaccinated against HPV and 6% had received partial vaccinations. Though male students understand the scope of HPV infection and perceive themselves to be at risk, are or intend to be vaccinated. This is a significant issue for public health, which needs to focus on this critical but neglected target population.