Although the effects of sex-role socialization factors on career decision-making have received increased attention, little research has assessed the relationship between sex role variables and the factors affecting career decision-making. Differential effects and interactions of sex, sex role orientation, and sex role attitudes on six factors affecting career decision making were assessed in a sample of college students (N=270), who completed the Bem Sex Role Inventory, Attitudes Toward Women Scale, and the Career Factor Checklist. Analysis of variance revealed significant differences or interactions for subjects depending on their sex, sex role orientation, and sex role attitude for the familial, individual, situational, and psychosocial-emotional factors. Sex differences were found for the psychosocial-emotional factors, with men reporting a greater effect of these problem areas than women. Main effects for sex role orientation were found for the familial, individual, and psychosocial-emotional factors. Results indicated significant interactions of sex role orientation and attitude for the familial factor and a triple interaction of sex, sex role attitude, and sex role orientation for the situational factor. The main effect for sex role orientation on the psychosocial-emotional factor supports the notion that androgynous people are more psychologically functional and adjusted. (Author/NRB)