The authors evaluated an 8-week, 2-hr per week training for physicians, nurses, chaplains, and other health professionals using nonsectarian, spiritually based self-management tools based on passage meditation (E. Easwaran, 1978/1991). Participants were randomized to intervention (n = 27) or waiting list (n = 31). Pretest, posttest, and 8-and 19-week follow-up data were gathered on 8 measures, including perceived stress, burnout, mental health, and psychological well-being. Aggregated across examinations, beneficial treatment effects were observed on stress (p = 0.0013) and mental health (p = 0.03). Treatment effects on stress were mediated by adherence to practices (p = 0.05). Stress reductions remained large at 19 weeks (84% of the pretest standard deviation, p = 0.006). Evidence suggests this program reduces stress and may enhance mental health.