This article examines the effects of transformational leadership of supervisors and the sense of calling on job burnout among special education teachers. A total of 256 special education teachers completed the Maslach Burnout Inventory and rated their supervisors on the Multifactor Leadership Questionnaire. The results reveal that transformational leadership was negatively related to emotional exhaustion and depersonalization and positively related to personal accomplishment. Moreover, the present study indicates that the relationship between transformational leadership and teachers' burnout was mediated by the sense of calling. This finding suggests that transformational leadership indirectly affects job burnout by developing a sense of calling in followers or helping them find meaning and purpose in their experiences through transformational leadership behaviors, which can ultimately protect followers from being exposed to emotional exhaustion and depersonalization and enhance the feeling of personal accomplishment.