The Nigerian tertiary educational system has been ravaged by incessant strike action, which appears to defy all attempts to find solutions. This paper reports on a study that examines the impact of job satisfaction and burnout on attitudes towards strike actions among employees of a Nigerian university. A total of 576 employees participated in the study, 263 men and 313 women, with a mean age of 38.49 years. The Attitude to Strike Scale, Minnesota Satisfaction Questionnaire-Short Form, and Teacher's Burnout Scale were used to collect data. Findings showed that employees with low job satisfaction and high burnout reported significantly a more positive attitude towards strike action than those with higher job satisfaction and lower burnout. It was suggested that governments and administrators of Nigerian tertiary institutions should device strategies to improve workers' job satisfaction and reduce burnout as ways of reducing the workers' likelihood to embark on strike actions.