Our knowledge "system" is built up from disciplines and specialties as its components, which are "wired" by patterns of collaboration that constitute its organization. The intellectual autonomy of these components prevents this knowledge system from adequately accounting for what we have gradually discovered during the past 50 years: In human life, society, and the biosphere, everything is related to everything else. It has also created a dual mode of knowing and doing, one embedded in experience and culture and the other separated from them. It is becoming increasingly evident that the lacunae in our knowledge system are directly related to the challenges faced by our civilization. This article outlines a proposal to begin delimiting these lacunae by inserting new components on the basis of roundtables into the knowledge system.