To promote math and science, this author designed an activity to show students that biomedical fields are within their reach. The activity has three distinct goals: (1) To introduce the field of biomedical engineering to students and encourage them in these career pursuits; (2) To give them hands-on experience conducting a biomechanical test; and (3) To use math and science to analyze data and answer a real-world question: Does knotting a suture (the fiber used to stitch an incision closed) strengthen or weaken it? This article describes how this activity was implemented at the fifth-grade level. It also describes how to develop and implement a suture activity for a high school classroom. (Contains 4 figures.)