Recent scholarship indicates that people who view their work as a calling are more satisfied with their work and their lives. Historically, calling has been regarded as a religious experience, although modern researchers frequently have adopted a more expansive and secular conceptualization of calling, emphasizing meaning and personal fulfillment in work. The assumption that calling can be easily secularized and applied has not been tested. Therefore, we tested whether calling was related to psychological adjustment and positive work attitudes of both highly religious and less religious college students (N = 242). We also tested whether these positive relations were mediated by people's intrinsic religiousness or by a broader, secular construct, meaning in life. Moderation-mediation analyses supported views of calling centering on people's experience of meaning in their work rather than more constrained religious views. Implications for future research and practical applications of calling to positive work attitudes are discussed. (Contains 2 tables.)