"Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This Brief summarizes the findings and implications of "Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice" (I. Y. Choi; A. M. Allan; and L. A. Cunningham). Observations of mice from birth through young adulthood showed that fetal exposure to alcohol alters the development of brain architecture and can disturb adult brain plasticity by impeding the survival of neurons produced in adulthood and impairing the brain's ability to remodel itself later in life. [Title and Authors: Choi, I.Y., Allan, A.M., Cunningham, L.A. (2005) Moderate fetal alcohol exposure impairs the neurogenic response to an enriched environment in adult mice. "Alcoholism: Clinical and Experimental Research" 29:2053-2062.]