Two case reports are described in which patients presented for the treatment of multiple comorbid anxiety disorders, all of which appeared to derive from prolonged separation anxiety disorder. In particular, these adults had effectively altered their lifestyles to avoid separation, thereby displaying only ambiguous separation anxiety symptoms that initially seemed attributable to their comorbid anxiety disorders. These reports highlight the complex nature of separation anxiety disorder in adulthood, as well as the substantial impairment to the patients' lives that occurred in coping with the disorder. Lastly, difficulties in identifying the disorder in the presence of comorbid anxiety are discussed.